Communications Biology (Jun 2021)

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

  • Wim H. Quint,
  • Kirke C. D. Tadema,
  • Erik de Vrieze,
  • Rachel M. Lukowicz,
  • Sanne Broekman,
  • Beerend H. J. Winkelman,
  • Melanie Hoevenaars,
  • H. Martijn de Gruiter,
  • Erwin van Wijk,
  • Frank Schaeffel,
  • Magda Meester-Smoor,
  • Adam C. Miller,
  • Rob Willemsen,
  • Caroline C. W. Klaver,
  • Adriana I. Iglesias

DOI
https://doi.org/10.1038/s42003-021-02185-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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Quint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b, previously found in the retina, possesses an additional lenticular role.