Network of hotspot interactions cluster tau amyloid folds

Vishruth Mullapudi; Jaime Vaquer-Alicea; Vaibhav Bommareddy; Anthony R. Vega; Bryan D. Ryder; Charles L. White; Marc. I. Diamond; Lukasz A. Joachimiak

doi:10.1038/s41467-023-36572-3

Nature Communications (Feb 2023)

Affiliations

Vishruth Mullapudi: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Jaime Vaquer-Alicea: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Vaibhav Bommareddy: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Anthony R. Vega: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Bryan D. Ryder: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Charles L. White: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Marc. I. Diamond: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center
Lukasz A. Joachimiak: Center for Alzheimer’s and Neurodegenerative Diseases, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-023-36572-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 19

Abstract

Read online

The authors developed a computational approach to probe the stability of amyloid fibrils and discover networks of hotspot interactions. Understanding the mechanisms of amyloid folding will help identify novel methods to treat protein (mis)folding diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal