Frontiers in Bioengineering and Biotechnology (Feb 2023)

Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19

  • Ping-Yuan Lin,
  • Yi-Wei Chung,
  • Yi-Wei Chung,
  • Yi-Wei Chung,
  • Yi-Wei Chung,
  • Er-Yuan Chuang,
  • Yen-Chieh Wang,
  • Min-Chih Lai,
  • Yen-Chin Hsu,
  • Chun-Che Lin,
  • Yu-Cheng Hsiao,
  • Yu-Cheng Hsiao,
  • Yu-Cheng Hsiao,
  • Yu-Cheng Hsiao

DOI
https://doi.org/10.3389/fbioe.2023.1148446
Journal volume & issue
Vol. 11

Abstract

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Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.

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