Nature Communications (Oct 2020)

AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation

  • Han Tian,
  • Rong Lian,
  • Yun Li,
  • Chenying Liu,
  • Shujun Liang,
  • Wei Li,
  • Tianyu Tao,
  • Xingui Wu,
  • Yaokai Ye,
  • Xia Yang,
  • Jian Han,
  • Xuwei Chen,
  • Jun Li,
  • Yukai He,
  • Mengfeng Li,
  • Jueheng Wu,
  • Junchao Cai

DOI
https://doi.org/10.1038/s41467-020-18929-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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The role of long non-coding RNA (lncRNA) in AKT-driven tumor development is unclear. Here, the authors identify VAL (Vimentin associated lncRNA) to be directly induced by AKT/STAT3 signaling and report a lncRNA-mediated mechanism for active AKT-driven EMT-independent lung adenocarcinoma metastasis.