An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

Abstract

The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.

Keywords

• 1,4-diketone
• migration and cyclization
• pyrrolo[1,2-b]pyridazine
• tertiary butyl carbamate
• tertiary butyl carbazate
• α,β-unsaturated ketone