Melanopsin (Opn4) is an oncogene in cutaneous melanoma

Leonardo Vinícius Monteiro de Assis; José Thalles Lacerda; Maria Nathália Moraes; Omar Alberto Domínguez-Amorocho; Gabriela Sarti Kinker; Davi Mendes; Matheus Molina Silva; Carlos Frederico Martins Menck; Niels Olsen Saraiva Câmara; Ana Maria de Lauro Castrucci

doi:10.1038/s42003-022-03425-6

Communications Biology (May 2022)

Melanopsin (Opn4) is an oncogene in cutaneous melanoma

Leonardo Vinícius Monteiro de Assis,
José Thalles Lacerda,
Maria Nathália Moraes,
Omar Alberto Domínguez-Amorocho,
Gabriela Sarti Kinker,
Davi Mendes,
Matheus Molina Silva,
Carlos Frederico Martins Menck,
Niels Olsen Saraiva Câmara,
Ana Maria de Lauro Castrucci

Affiliations

Leonardo Vinícius Monteiro de Assis: Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo
José Thalles Lacerda: Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo
Maria Nathália Moraes: Laboratory of Neurobiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo
Omar Alberto Domínguez-Amorocho: Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of São Paulo
Gabriela Sarti Kinker: Laboratory of Translational Immuno-Oncology A. C. Camargo Cancer Center – International Research Center
Davi Mendes: DNA Repair Lab, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP)
Matheus Molina Silva: DNA Repair Lab, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP)
Carlos Frederico Martins Menck: DNA Repair Lab, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP)
Niels Olsen Saraiva Câmara: Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of São Paulo
Ana Maria de Lauro Castrucci: Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo

DOI: https://doi.org/10.1038/s42003-022-03425-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Melanopsin (Opn4) is identified as an oncogene in cutaneous melanoma, with the loss of Opn4 found to be associated with reduced proliferation and tumor growth, due to changes in immune responses and Mitf signaling in vitro and in vivo.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal