Nature Communications (Jul 2019)

Membrane protein-regulated networks across human cancers

  • Chun-Yu Lin,
  • Chia-Hwa Lee,
  • Yi-Hsuan Chuang,
  • Jung-Yu Lee,
  • Yi-Yuan Chiu,
  • Yan-Hwa Wu Lee,
  • Yuh-Jyh Jong,
  • Jenn-Kang Hwang,
  • Sing-Han Huang,
  • Li-Ching Chen,
  • Chih-Hsiung Wu,
  • Shih-Hsin Tu,
  • Yuan-Soon Ho,
  • Jinn-Moon Yang

DOI
https://doi.org/10.1038/s41467-019-10920-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

Membrane proteins have been implicated in cancers, but studying the downstream effects of their perturbation remains challenging. Here, the authors map the membrane protein-regulated network of 15 cancers, a resource for prognostic biomarker development and druggable target identification.