Antibacterial and Cytotoxic Activities of Diterpenoids Isolated from Indian Plectranthus coesta

Records of Natural Products. 2013;7(4):355-358

 

Journal Homepage

Journal Title: Records of Natural Products

ISSN: 1307-6167 (Print)

Publisher: ACG Publications

LCC Subject Category: Science: Chemistry: Organic chemistry | Science: Botany

Country of publisher: Turkey

Language of fulltext: English

Full-text formats available: PDF

 

AUTHORS

Shobha Waldia (Department of Chemistry, L.S.M. Govt. PG College Pithoragarh, Kumaun University, Nainital, Uttarakhand, 262501, India. )
Nagendra Kaushik (Department of Chemistry, University of Delhi, Delhi-110007, India. Department of Chemistry, Kwangwoon University, Seoul-139701, South Korea)
Akhilesh K. Verma (Department of Chemistry, University of Delhi, Delhi-110007, India. )
Bipin C. Joshi (Department of Chemistry, L.S.M. Govt. PG College Pithoragarh, Kumaun University, Nainital, Uttarakhand, 262501, India. )
Uma Pathak (Department of Chemistry, L.S.M. Govt. PG College Pithoragarh, Kumaun University, Nainital, Uttarakhand, 262501, India. )
Mukesh C. Joshi (Department of Chemistry, University of Delhi, Delhi-110007, India. Department of Chemistry, Motilal Nehru College, Benito Juarez Marg, Delhi University, South Campus, New Delhi-110021, India. )

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 6 weeks

 

Abstract | Full Text

Plectranthus is known for its medicinal value . The paper describes the antibacterial and cytotoxic activity of diterpenoids ent -7-hydroxykaur-15,16-en-19-oic acid (1), 17-oxokaur-15,16-en-19-oic acid (2) and ent-7-hydroxy-15,16-epoxykauran-19-oic acid (3), isolated from the shade-dried and powdered leaves of Indian Plactranthus coesta. Diterpenoid 3 was isolated for the first time from Indian P. coesta . Diterpenoid 1, shows potent activity against E. coli (15.6 µg/mL), P. aureginosa (17 µg/mL) and K. planticola (32.5 µg/mL), while diterpenoid 2, also showed good activity against E. coli (61 µg/mL), P. aureginosa (61 µg/mL), K. planticola (61 µg/mL) and S. epidermidis (125 µg/mL). Diterpenoids 1-3 were found to be more efficacious on U87 cancer cells and less toxic on normal human HEK and HeLa cells.