Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum

Caitlin A. Brennan; Geicho Nakatsu; Carey Ann Gallini Comeau; David A. Drew; Jonathan N. Glickman; Robert E. Schoen; Andrew T. Chan; Wendy S. Garrett

doi:10.1128/mBio.00547-21

mBio (Apr 2021)

Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum

Caitlin A. Brennan,
Geicho Nakatsu,
Carey Ann Gallini Comeau,
David A. Drew,
Jonathan N. Glickman,
Robert E. Schoen,
Andrew T. Chan,
Wendy S. Garrett

Affiliations

Caitlin A. Brennan: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
Geicho Nakatsu: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
Carey Ann Gallini Comeau: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
David A. Drew: Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Jonathan N. Glickman: Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
Robert E. Schoen: Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Andrew T. Chan: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
Wendy S. Garrett: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

DOI: https://doi.org/10.1128/mBio.00547-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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There is an increasing understanding of the clinical correlations and potential mechanistic roles of specific members of the gut and tumoral microbiota in colorectal cancer (CRC) initiation, progression, and survival. However, we have yet to parlay this knowledge into better CRC outcomes through microbially informed diagnostic, preventive, or therapeutic approaches.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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