Frontiers in Nutrition (Sep 2022)
Association of circulating branched-chain amino acids with risk of moyamoya disease
- Chaofan Zeng,
- Chaofan Zeng,
- Chaofan Zeng,
- Chaofan Zeng,
- Chaofan Zeng,
- Peicong Ge,
- Peicong Ge,
- Peicong Ge,
- Peicong Ge,
- Peicong Ge,
- Chenglong Liu,
- Chenglong Liu,
- Chenglong Liu,
- Chenglong Liu,
- Chenglong Liu,
- Xiaofan Yu,
- Xiaofan Yu,
- Xiaofan Yu,
- Xiaofan Yu,
- Xiaofan Yu,
- Yuanren Zhai,
- Yuanren Zhai,
- Yuanren Zhai,
- Yuanren Zhai,
- Yuanren Zhai,
- Wei Liu,
- Wei Liu,
- Wei Liu,
- Wei Liu,
- Wei Liu,
- Qiheng He,
- Qiheng He,
- Qiheng He,
- Qiheng He,
- Qiheng He,
- Junsheng Li,
- Junsheng Li,
- Junsheng Li,
- Junsheng Li,
- Junsheng Li,
- Xingju Liu,
- Xingju Liu,
- Xingju Liu,
- Xingju Liu,
- Xingju Liu,
- Jia Wang,
- Jia Wang,
- Jia Wang,
- Jia Wang,
- Jia Wang,
- Xun Ye,
- Xun Ye,
- Xun Ye,
- Xun Ye,
- Xun Ye,
- Qian Zhang,
- Qian Zhang,
- Qian Zhang,
- Qian Zhang,
- Qian Zhang,
- Rong Wang,
- Rong Wang,
- Rong Wang,
- Rong Wang,
- Rong Wang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Jizong Zhao,
- Jizong Zhao,
- Jizong Zhao,
- Jizong Zhao,
- Jizong Zhao,
- Dong Zhang,
- Dong Zhang,
- Dong Zhang,
- Dong Zhang,
- Dong Zhang,
- Dong Zhang
Affiliations
- Chaofan Zeng
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Chaofan Zeng
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Chaofan Zeng
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Chaofan Zeng
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Chaofan Zeng
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Peicong Ge
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Peicong Ge
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Peicong Ge
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Peicong Ge
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Peicong Ge
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Chenglong Liu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Chenglong Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Chenglong Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Chenglong Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Chenglong Liu
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Xiaofan Yu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xiaofan Yu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xiaofan Yu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xiaofan Yu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xiaofan Yu
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Yuanren Zhai
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yuanren Zhai
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yuanren Zhai
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yuanren Zhai
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yuanren Zhai
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Wei Liu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Wei Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Wei Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Wei Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Wei Liu
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Qiheng He
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Qiheng He
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Qiheng He
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Qiheng He
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Qiheng He
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Junsheng Li
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Junsheng Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Junsheng Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Junsheng Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Junsheng Li
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Xingju Liu
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xingju Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xingju Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xingju Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xingju Liu
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Jia Wang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Jia Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Jia Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Jia Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jia Wang
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Xun Ye
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xun Ye
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xun Ye
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xun Ye
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xun Ye
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Qian Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Qian Zhang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Qian Zhang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Qian Zhang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Qian Zhang
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Rong Wang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Rong Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Rong Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Rong Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Rong Wang
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Yan Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yan Zhang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yan Zhang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yan Zhang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yan Zhang
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Jizong Zhao
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Jizong Zhao
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Jizong Zhao
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Jizong Zhao
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jizong Zhao
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Dong Zhang
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Dong Zhang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Dong Zhang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Dong Zhang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Dong Zhang
- Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China
- Dong Zhang
- Department of Neurosurgery, Beijing Hospital, Beijing, China
- DOI
- https://doi.org/10.3389/fnut.2022.994286
- Journal volume & issue
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Vol. 9
Abstract
ObjectiveBranched-Chain Amino Acids (BCAAs) has been identified as a risk factor for circulatory disease. Nevertheless, the effects and mechanisms of BCAAs on the risk of moyamoya disease (MMD) remain unrecognized. Hence, we aimed to elucidate the association between circulating BCAAs and the risk of MMD and clinical subtypes.MethodsWe conducted a case-control study of 360 adult MMD patients and 89 matched healthy controls consecutively recruited between September 2020 and December 2021. Serum level of BCAAs was quantified by liquid chromatography-mass spectrometry. The associations between BCAAs and risk of MMD were evaluated.ResultsIncreased level of serum BCAAs was observed in MMD patients (P < 0.001). After adjusting for traditional confounders, the elevated BCAAs level was significantly associated with the risk of MMD (Q4 vs. Q1: odds ratio, 3.10 [95% CI, 1.29–7.50]). The risk of subtypes in MMD also increased with each increment in the quartiles of BCAAs. Furthermore, BCAAs offered substantial improvement in risk reclassification and discrimination for MMD and subtypes.ConclusionHigher level of circulating BCAAs was associated with increased risk of MMD and clinical subtypes. This study will help to elucidate the pathogenesis of MMD, which may provide the support for facilitating the treatments and preventions.
Keywords
