Incidence rate of celiac disease in patients withchronic diarrhea

Abstract

Aim. To study prevalence of celiac disease (CD) among patients with chronic diarrhea (ChD). Material and methods. Serum levels of IgA-antibodies to gliadin, endomysium, reticulin and tissue transglutaminase were examined in 206 patients with CD. Biopsies were obtained from a distal portion of the duodenum or a proximal portion of the jejunum. Results. CD was diagnosed in 35 (16.9%) of 206 patients with ChD. The disease was typical in 5 (2.4%) patients and was latent in 30 (14.5%) patients. Antibodies to gliadin, endomysium, reticulin and tissues transglutaminase in diagnostically significant titers were detected in the serum of all the examinees with CD. Formation of the antitissue antibodies occurred because of destructive-dystrophic alterations of the connective tissue of the lamina propria mucosae pointing to the autoimmune nature of a pathological process in celiac disease. Conclusion. To diagnose CD in ChD patients, it is necessary to supplement standard examination with duodenobiopsy, tests for antibodies to gliadin, tissue transglutaminase and to tissue structures - endomysium and reticulin.

Keywords

• celiac disease
• antigliadin antibodies
• antiendomysial antibodies
• antireticuline antibodies
• tissue transglutaminase antibodies