Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

Abstract

The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key intermediates of the mHsp60-mHsp10 reaction cycle.