Nature Communications (Jun 2018)
Efficient RNA drug delivery using red blood cell extracellular vesicles
- Waqas Muhammad Usman,
- Tin Chanh Pham,
- Yuk Yan Kwok,
- Luyen Tien Vu,
- Victor Ma,
- Boya Peng,
- Yuen San Chan,
- Likun Wei,
- Siew Mei Chin,
- Ajijur Azad,
- Alex Bai-Liang He,
- Anskar Y. H. Leung,
- Mengsu Yang,
- Ng Shyh-Chang,
- William C. Cho,
- Jiahai Shi,
- Minh T. N. Le
Affiliations
- Waqas Muhammad Usman
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Tin Chanh Pham
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Yuk Yan Kwok
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Luyen Tien Vu
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Victor Ma
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Boya Peng
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Yuen San Chan
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Likun Wei
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Siew Mei Chin
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Ajijur Azad
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Alex Bai-Liang He
- Queen Mary Hospital and Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Anskar Y. H. Leung
- Queen Mary Hospital and Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Mengsu Yang
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Ng Shyh-Chang
- Genome Institute of Singapore
- William C. Cho
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Jiahai Shi
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- Minh T. N. Le
- Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-018-04791-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.
