Ulinastatin alleviates traumatic brain injury by reducing endothelin-1

Abstract

Brain edema is one of the major causes of fatality and disability associated with injury and neurosurgical procedures. The goal of this study was to evaluate the effect of ulinastatin (UTI), a protease inhibitor, on astrocytes in a rat model of traumatic brain injury (TBI).

Keywords

• ulinastatin
• traumatic brain injury
• brain edema
• astrocyte
• endothelin-1