Utility of p63 in Giant Cell Lesions of Bone- A Case Series

Abstract

Giant cell lesions of bone include a relatively large group of biologically and morphologically diverse bone lesions which shows presence of numerous multinucleate osteoclast like giant cells. Recently, p63 has been found to be a sensitive marker in the diagnosis of giant cell tumour. The aim of this case series is to assess the role of p63 in diagnostically difficult giant cell lesions of bone. The authors here present four cases with giant cell rich lesions of bone as seen in Hematoxylin and Eosin (H&E) staining, in which an accurate diagnosis was not possible with the available clinical and radiological data were included in this study. The tissue was stained with hematoxylin and eosin and Immunohistochemical staining (IHC) with p63 was done. Though the specificity of the marker was found to be less, it was concluded that, p63 can be used as an ancillary aid along with histomorphological and radiological data in arriving at a diagnosis.

Keywords

• aneurysmal bone cysts
• immunohistochemistry
• non neoplastic lesions