Pneumon (Jun 2023)
Epidemiological characteristics, clinical features and outcomes of patients with COVID-19 admitted to seven reference centers across Greece: An observational study during the fourth and fifth waves of the COVID-19 pandemic
- Ourania Papaioannou,
- Theodoros Karampitsakos,
- Panagiota Tsiri,
- Vagia Karageorgou,
- Andriana I. Papaioannou,
- Maria Kallieri,
- Myrto Blizou,
- Stefanos Lampadakis,
- Maria Sfika,
- Antonios Krouskos,
- Vasilis Papavasileiou,
- Franceska Strakosha,
- Kalliopi-Theoni Vandorou,
- Pavlos Siozos,
- Marina Moustaka- Christodoulou,
- Georgia Kontonasiou,
- Vasiliki Apollonatou,
- Elvira-Markella Antonogiannaki,
- Christos Kyriakopoulos,
- Christina Aggelopoulou,
- Christos Chronis,
- Konstantinos Kostikas,
- Evangelia Koukaki,
- Zoi Sotiropoulou,
- Athanasia Athanasopoulou,
- Petros Bakakos,
- Pinelopi Sxini,
- Emmanouil Alevrakis,
- Sotirios Poupos,
- Evangelia Xondrou,
- Dionisios Tsoukalas,
- Alexia Chronaiou,
- George Tsoukalas,
- Sofia Koukidou,
- Georgios Hillas,
- Katerina Dimakou,
- Konstantinos Roukas,
- Ifigenia Nakou,
- Diamantis Chloros,
- Evangelia Fouka,
- Spyros A. Papiris,
- Stelios Loukides,
- Argyrios Tzouvelekis
Affiliations
- Ourania Papaioannou
- ORCiD
- Department of Respiratory Medicine, University Hospital of Patras, Patra, Greece
- Theodoros Karampitsakos
- Department of Respiratory Medicine, University Hospital of Patras, Patra, Greece
- Panagiota Tsiri
- Department of Respiratory Medicine, University Hospital of Patras, Patra, Greece
- Vagia Karageorgou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Andriana I. Papaioannou
- 1st Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Maria Kallieri
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Myrto Blizou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Stefanos Lampadakis
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Maria Sfika
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Antonios Krouskos
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Vasilis Papavasileiou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Franceska Strakosha
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Kalliopi-Theoni Vandorou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Pavlos Siozos
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Marina Moustaka- Christodoulou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Georgia Kontonasiou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Vasiliki Apollonatou
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Elvira-Markella Antonogiannaki
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Christos Kyriakopoulos
- Department of Respiratory Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece
- Christina Aggelopoulou
- Department of Respiratory Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece
- Christos Chronis
- Department of Respiratory Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece
- Konstantinos Kostikas
- Department of Respiratory Medicine, Faculty of Medicine, University of Ioannina, Ioannina, Greece
- Evangelia Koukaki
- 1st Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Zoi Sotiropoulou
- 1st Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Athanasia Athanasopoulou
- 1st Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Petros Bakakos
- 1st Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Pinelopi Sxini
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Emmanouil Alevrakis
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Sotirios Poupos
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Evangelia Xondrou
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Dionisios Tsoukalas
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Alexia Chronaiou
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- George Tsoukalas
- 4th Respiratory Medicine Department, School of Medicine, National and Kapodistrian University of Athens, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Sofia Koukidou
- 5th Respiratory Medicine Department, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Georgios Hillas
- 5th Respiratory Medicine Department, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Katerina Dimakou
- 5th Respiratory Medicine Department, ‘Sotiria’ Chest Diseases Hospital, Athens, Greece
- Konstantinos Roukas
- COVID-19 Clinic, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece
- Ifigenia Nakou
- COVID-19 Clinic, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece
- Diamantis Chloros
- COVID-19 Clinic, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece
- Evangelia Fouka
- COVID-19 Clinic, Aristotle University of Thessaloniki, G. Papanikolaou Hospital, Thessaloniki, Greece
- Spyros A. Papiris
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Stelios Loukides
- 2nd Respiratory Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
- Argyrios Tzouvelekis
- Department of Respiratory Medicine, University Hospital of Patras, Patra, Greece
- DOI
- https://doi.org/10.18332/pne/163036
- Journal volume & issue
-
Vol. 36,
no. 2
pp. 1 – 8
Abstract
Introduction Epidemiological data from hospitalized patients with COVID-19 during the fourth and fifth waves of the pandemic have been published worldwide. Methods This registry was an observational, prospective study conducted in seven reference hospitals across Greece. Maximum FiO 2 during hospitalization and Charlson comorbidity index (CCI) on admission were correlated with disease severity, as well as radiological features, parameters of complete blood count, and d-dimer. Results A total of 1019 patients were included in the analysis; 55.1% and 57.2% of patients were males and never smokers, respectively, with median age of 67 years (95% CI: 65.7–69.0). Patients with increased extent of consolidation and ground glass opacities in chest CT (>10–25%) exhibited more advanced disease compared to the low extent group (<10%) as indicated by both CCI on admission (3; 95% CI: 2–3 vs 2; 95% CI: 1–2, p=0.0002) and MaxFiO 2 (0.40; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.24–0.28, p<0.0001). Patients with high neutrophil to lymphocyte ratio (≥4.42) exhibited more severe disease as indicated by significantly increased CCI on admission (4; 95% CI: 3 to 4 vs 3; 95% CI: 2–3, p<0.0001) and MaxFiO 2 (0.35; 95% CI: 0.35–0.4 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). Patients with elevated d-dimer (≥0.74 μg/mL) displayed also advanced disease compared to the low d-dimer group (<0.74 μg/mL), as assessed by both CCI on admission (4; 95% CI: 4–4 vs 2; 95% CI: 2–2, p<0.0001) and MaxFiO 2 (0.38; 95% CI: 0.35–0.40 vs 0.28; 95% CI: 0.28–0.28, p<0.0001). Conclusions We present the first observational study across Greece during the fourth and fifth waves of the COVID-19 pandemic. Extent of opacities in chest CT, neutrophil to lymphocyte ratio and d-dimer may represent reliable disease prognostic factors leading to timely therapeutic interventions.
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