Nature Communications (Jul 2022)
Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression
- Xinyuan Lei,
- Hsinyu Lin,
- Jieqi Wang,
- Zhanpeng Ou,
- Yi Ruan,
- Ananthan Sadagopan,
- Weixiong Chen,
- Shule Xie,
- Baisheng Chen,
- Qunxing Li,
- Jue Wang,
- Huayue Lin,
- Xiaofeng Zhu,
- Xiaoqing Yuan,
- Tian Tian,
- Xiaobin Lv,
- Sha Fu,
- Xiaorui Zhu,
- Jian Zhou,
- Guokai Pan,
- Xin Xia,
- Bakhos A. Tannous,
- Soldano Ferrone,
- Song Fan,
- Jinsong Li
Affiliations
- Xinyuan Lei
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Hsinyu Lin
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Jieqi Wang
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Zhanpeng Ou
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Yi Ruan
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Ananthan Sadagopan
- Department of Surgery, Massachusetts General Hospital, Harvard Medical School
- Weixiong Chen
- Department of Stomatology, Longgang District Central Hospital, Affiliated to Guangzhou University of Traditional Chinese Medicine
- Shule Xie
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Baisheng Chen
- Department of Thoracic Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Qunxing Li
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Jue Wang
- Cellular Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Huayue Lin
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital
- Xiaofeng Zhu
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital
- Xiaoqing Yuan
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital
- Tian Tian
- Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University
- Xiaobin Lv
- Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory, the Third Affiliated Hospital, Nanchang University
- Sha Fu
- Cellular Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Xiaorui Zhu
- Department of Chronic Diseases Epidemiology, Yale University of Public Health
- Jian Zhou
- Department of Medical Imaging, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Guokai Pan
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Xin Xia
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Bakhos A. Tannous
- Experimental Therapeutics and Molecular Imaging Lab, Department of Neurology, Massachusetts General Hospital and Harvard Medical School
- Soldano Ferrone
- Department of Surgery, Massachusetts General Hospital, Harvard Medical School
- Song Fan
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Jinsong Li
- Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s41467-022-31417-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Cancer cells downregulate surface expression of major histocompatibility complex I (MHC-I) for immune evasion. Here, the authors show that rapid mitochondrial fission activates the ER-stress response leading to reduced MHC-I complex formation and cell surface expression in solid cancer cells; moreover inhibition of mitochondrial fission increases the immune-mediated anticancer response in murine models.
