Nature Communications (Oct 2020)
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
- Hiroki Inada,
- Miyako Udono,
- Kanae Matsuda-Ito,
- Kenichi Horisawa,
- Yasuyuki Ohkawa,
- Shizuka Miura,
- Takeshi Goya,
- Junpei Yamamoto,
- Masao Nagasaki,
- Kazuko Ueno,
- Daisuke Saitou,
- Mikita Suyama,
- Yoshihiko Maehara,
- Wataru Kumamaru,
- Yoshihiro Ogawa,
- Sayaka Sekiya,
- Atsushi Suzuki
Affiliations
- Hiroki Inada
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Miyako Udono
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Kanae Matsuda-Ito
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Kenichi Horisawa
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Yasuyuki Ohkawa
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Shizuka Miura
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Takeshi Goya
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Junpei Yamamoto
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Masao Nagasaki
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Kazuko Ueno
- Genome Medical Science Project, National Center for Global Health and Medicine
- Daisuke Saitou
- Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University
- Mikita Suyama
- Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University
- Yoshihiko Maehara
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
- Wataru Kumamaru
- Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
- Yoshihiro Ogawa
- Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
- Sayaka Sekiya
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- Atsushi Suzuki
- Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
- DOI
- https://doi.org/10.1038/s41467-020-19041-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and cholangiocytes that reconstitute damaged liver tissues on transplantation.
