A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

Jan Marten Schmidt; Ran Yang; Ashish Kumar; Olivia Hunker; Jan Seebacher; Franziska Bleichert

doi:10.1038/s41467-022-28695-w

Nature Communications (Feb 2022)

A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

Jan Marten Schmidt,
Ran Yang,
Ashish Kumar,
Olivia Hunker,
Jan Seebacher,
Franziska Bleichert

Affiliations

Jan Marten Schmidt: Friedrich Miescher Institute for Biomedical Research
Ran Yang: Department of Molecular Biophysics and Biochemistry, Yale University
Ashish Kumar: Department of Molecular Biophysics and Biochemistry, Yale University
Olivia Hunker: Department of Molecular Biophysics and Biochemistry, Yale University
Jan Seebacher: Friedrich Miescher Institute for Biomedical Research
Franziska Bleichert: Department of Molecular Biophysics and Biochemistry, Yale University

DOI: https://doi.org/10.1038/s41467-022-28695-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Cryo-EM structures of S. cerevisiae ORC bound to DNA and Cdc6 reveal an autoinhibited conformation and suggest a mechanism of origin licensing control in response to CDK phosphorylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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