European Journal of Radiology Open (Jan 2014)

Current update on combined hepatocellular-cholangiocarcinoma

  • Suresh Maximin,
  • Dhakshina Moorthy Ganeshan,
  • Alampady K. Shanbhogue,
  • Manjiri K. Dighe,
  • Matthew M. Yeh,
  • Orpheus Kolokythas,
  • Puneet Bhargava,
  • Neeraj Lalwani

DOI
https://doi.org/10.1016/j.ejro.2014.07.001
Journal volume & issue
Vol. 1, no. C
pp. 40 – 48

Abstract

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Combined hepatocellular-cholangiocarcinoma is a rare but unique primary hepatic tumor with characteristic histology and tumor biology. Recent development in genetics and molecular biology support the fact that combined hepatocellular-cholangiocarcinoma is closely linked with cholangiocarcinoma, rather than hepatocellular carcinoma. Combined hepatocellular cholangiocarcinoma tends to present with an more aggressive behavior and a poorer prognosis than either hepatocellular carcinoma or cholangiocarcinoma. An accurate preoperative diagnosis and aggressive treatment planning can play crucial roles in appropriate patient management.

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