Monitoring post-approval drug safety in pregnancy: pharmacogenetic aspects

Abstract

The purpose of this article is to describe and to examine the utility of new pharmacogenetic approaches in monitoring post-approval drug safety in pregnancy. Data on gene expression in pregnancy and metabolic variation may, in specific instances, help to predict adverse drug reactions in the mother-placenta-fetus complex and to identify individuals at a higher risk.

Keywords

• беременность
• лекарственное средство
• безопасность
• фармакогенетика
• фармаконадзор
• pregnancy
• drugs
• safety
• pharmacogenetics
• pharmacovigilance