Chronic kidney disease (CKD) is a major disease that seriously endangers human health. Traditional Chinese medicine (TCM) has certain characteristic effect in the prevention and treatment of CKD, especially in reducing urinary proteins, protecting renal function, delaying the progress of CKD and alleviating related complications. This study reviews the new understanding of TCM theory of CKD in recent years, and summarizes the evidence-based medical evidence of the efficacy of TCM in the treatment of CKD and the new progress related to the effect mechanism of TCM treatment of CKD, summarizing the current situation of clinical and basic research and achievements transformation of CKD, and proposes future research prospects, in order to contribute to the further innovation and development of TCM in the prevention and treatment of CKD.