SWEmean of Quadriceps, a Potential Index of Complication Evaluation to Patients with Chronic Obstructive Pulmonary Disease

Abstract

Yifan Niu,1,2,* Yuanyuan Yue,1,* Yuqiong Zheng,3 Chengqin Long,3 Qunying Li,3 Yunfeng Chen,3 Zhichao Chen,4 Xiaojuan Ma11Department of Ultrasound, Chengdu First People’s Hospital, Chengdu, Sichuan, 610041, People’s Republic of China; 2School of Medical Imaging, North Sichuan Medical College, Nanchong, Sichuan, 637100, People’s Republic of China; 3Department of Respiratory, Chengdu First People’s Hospital, Chengdu, Sichuan, 610041, People’s Republic of China; 4Department of Orthopedics, Chengdu First People’s Hospital, Chengdu, Sichuan, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaojuan Ma, Department of Ultrasound, Chengdu First People’s Hospital, 18 Vientiane North Road, Hi-tech Zone, Chengdu, Sichuan, 610041, People’s Republic of China, Tel [phone], Email [email protected]: To develop a potential quadriceps’ index of complication evaluation for patients with chronic obstructive pulmonary disease (COPD) which is simple, convenient, and quantifiable.Patients and Methods: We conducted a prospective study of 59 patients with COPD and 56 healthy controls recruited by the Chengdu First People’s Hospital. Grayscale ultrasound (US) of the rectus femoris was performed to measure thickness (RFthick) and cross-sectional area (RFcsa). Shear wave elastography was used to determine the mean elasticity index (SWEmean) of the rectus femoris (SWERFmean), vastus lateralis (SWEVLmean) and vastus medialis (SWEVMmean). Clinical features included dyspnea index score (modified British Medical Research Council (MMRC) score), COPD Assessment Test (CAT), the Five-Repetition Sit-to-Stand Test (5STS) and the Six-Minute Walk Test (6MWT). We compared the differences between US parameters and SWEmean in healthy controls and COPD patients. We also described the correlation between US parameters, SWEmean and clinical features of patients with COPD.Results: The intra-observer repeatability for the performance of using SWE to measure quadriceps stiffness was excellent (intraclass correlation coefficient (ICC)> 0.75, p < 0.001). There was a statistically significant difference in the SWEmean of the quadriceps (p < 0.001), but no significant difference in terms of RFthic and RFcsa (p > 0.05) between healthy controls and COPD patients. The SWERFmean was positively correlated with the 6MWT (r = 0.959, p < 0.001), and negatively related to the mMRC (r=− 0.825, p < 0.001), CAT (r=− 0.993, p < 0.001) and 5STS (r=− 0.936, p < 0.001). However, the RFthic, RFcsa, SWEVLmean and SWEVMmean were not correlated with clinical features (p > 0.05).Conclusion: As a supplement to US, SWE reflects changes of stiffness in the quadriceps of COPD patients, and can expanding the dimension of US for assessing the quadriceps. Furthermore, SWEmean was associated with clinical features, and represents a potential index with which to reflect the clinical features of COPD patients.Keywords: chronic obstructive pulmonary disease, shear wave elastography, quadriceps, clinical features

Keywords

• chronic obstructive pulmonary disease
• shear wave elastography
• quadriceps
• clinical features