A Comparison of the effect of three-dimensional music with dexamethasone on the carrageenan- induced inflammation in mature male rats

Abstract

Background & Objective: Inflammation is an undesirable condition resulted from the effect of Arachidonic Acid metabolites especially prostaglandins. With regard to the side-effects of chemical anti-inflammatory medicines, this study was done aiming at examining the effect of 3D music on the extent of inflammation. Materials and methods: In this experimental study, 20 male Wistar rats (200-250 g) were randomly divided into 4 groups of 5 each, including healthy control group, inflammatory control group, inflammatory recipient of 50 ml of carrageenan1%, treated inflammatory with 2 mg per kg body weight dexamethasone and treated inflammatory with three-dimensional music player (8h). Finally, CRP blood test and weight difference between the injected right foot and the left foot were measured. One-way analysis of variance (ANOVA) was used to analyze the data through SPSS software.There was a significant mean difference between groups, using Tukey test at (p <0.05). Results: CRP levels in treated groups by dexamethasone (10.6±3.24mg/l), and music (16±9.95mg/l), compared to the control group (37.8±5.24mg/l), were significantly decreased, which this decrease was more discernable in treated groups that received dexamethasone. The weight difference between the left and right foot in the treatment group (0.016±0.007g), (0.044±0.044g) compared to the control group (0.154±0.056g), was significantly decreased. Conclusion: Dexamethasone can remove inflammation and three-dimensional music can reduce inflammation less than dexamethasone in the inflammatory animals.

Keywords

• 3d music
• dexamethasone
• inflammation
• carrageenan
• rat