Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol

Yosuke Iizumi; Yoshihiro Sowa; Wakana Goi; Yuichi Aono; Motoki Watanabe; Yoichi Kurumida; Tomoshi Kameda; Kenichi Akaji; Masatoshi Kitagawa; Toshiyuki Sakai

doi:10.1038/s42003-022-03522-6

Communications Biology (Jun 2022)

Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol

Yosuke Iizumi,
Yoshihiro Sowa,
Wakana Goi,
Yuichi Aono,
Motoki Watanabe,
Yoichi Kurumida,
Tomoshi Kameda,
Kenichi Akaji,
Masatoshi Kitagawa,
Toshiyuki Sakai

Affiliations

Yosuke Iizumi: Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku
Yoshihiro Sowa: Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku
Wakana Goi: Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku
Yuichi Aono: Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku
Motoki Watanabe: Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku
Yoichi Kurumida: Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST)
Tomoshi Kameda: Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST)
Kenichi Akaji: Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku
Masatoshi Kitagawa: Department of Molecular Biology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu
Toshiyuki Sakai: Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku

DOI: https://doi.org/10.1038/s42003-022-03522-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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The natural product fucoxanthinol causes G1 arrest through decreasing the levels of ribosomal protein uS7, which directly binds and stabilises cyclin-dependent kinase 6.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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