BMC Public Health (Dec 2023)

Application of the ‘online assessment + FOBT at home’ to improve participation and the efficacy of opportunistic screening for colorectal cancer: a retrospective cohort study

  • Xudong Peng,
  • Gang Tang,
  • Yonghong Wang,
  • Fanling Zeng,
  • Yuedong Chen,
  • Weidan Zhang,
  • Chunmei Mo,
  • Yana Yang,
  • Shuang Li,
  • Lian Bai,
  • Dachun Xiao,
  • Guolian Zheng,
  • Wenhua Ran,
  • Cheng Chen,
  • Yonghong Yang,
  • Yuanze Gao,
  • Shuangwei Zhu,
  • Zheng Huang,
  • Dongqing Zhao,
  • Chaofeng Wu,
  • Li Xu,
  • Zhengqiang Wei

DOI
https://doi.org/10.1186/s12889-023-17426-5
Journal volume & issue
Vol. 23, no. 1
pp. 1 – 9

Abstract

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Abstract Background Colorectal cancer (CRC) screening faces two major challenges: insufficient screening coverage and poor adherence. A smartphone applet named “Early Screening Assistant (ESA)” was developed to create an online risk-assessment and fecal occult blood test (FOBT) at home. This retrospective study was designed to evaluate whether the new CRC screening strategy can improve the colonoscopy participation rate (PR) and lesion detection rate (DR). Methods In total, 6194 individuals who accepted normal health examinations and CRC screening based on the ESA from June 2020 to May 2022 were assigned to the ESA group. Accordingly, 7923 inhabitants who only accepted normal health examinations were assigned to the control group. The colonoscopy PR and neoplastic lesion DR were then compared between the two groups. Results Overall, a higher proportion of subjects in the ESA group (285 of 6194 [4.6%]) completed colonoscopy than in the control group (126 of 7923, [1.6%]), p < 0.01). The neoplastic lesion DR also significantly increased in the ESA group (76 of 6194 [1.22%]) compared with the control group (15 of 7923 [0.19%]) (p < 0.01). The adjusted diagnostic sensitivity and specificity of the “Online assessment + FOBT at home” were 41.5% and 62.6% for neoplastic lesions, respectively. Conclusions This retrospective cohort study confirmed that the new CRC screening strategy based on the “Online assessment + FOBT at home” can improve colonoscopy participation and the neoplastic lesion detection rate and may represent a promising screening strategy for CRC. Trial registration This study was registered in China Clinical Trial Registry ( https://www.chictr.org.cn ) on 29/09/2022. Registration number: ChiCTR2200064186.

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