Cerebral microcirculation mapped by echo particle tracking velocimetry quantifies the intracranial pressure and detects ischemia

Abstract

Hydrocephalus involves abnormal accumulation of cerebrospinal fluid, resulting in elevated intracranial pressure. The authors developed contrast-enhanced ultrasound imaging and intravascular microbubbles tracking in hydrocephalic pediatric porcine models to noninvasively assess intracranial pressure and detect cerebral ischemia.