Nature Communications (Nov 2022)
Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer
- Qiaoqi Sui,
- Xi Zhang,
- Chao Chen,
- Jinghua Tang,
- Jiehai Yu,
- Weihao Li,
- Kai Han,
- Wu Jiang,
- Leen Liao,
- Lingheng Kong,
- Yuan Li,
- Zhenlin Hou,
- Chi Zhou,
- Chenzhi Zhang,
- Linjie Zhang,
- Binyi Xiao,
- Weijian Mei,
- Yanbo Xu,
- Jiayi Qin,
- Jian Zheng,
- Zhizhong Pan,
- Pei-Rong Ding
Affiliations
- Qiaoqi Sui
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Xi Zhang
- BGI-Shenzhen
- Chao Chen
- Department of Thoracic Surgery, Peking University Shenzhen Hospital; Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center
- Jinghua Tang
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Jiehai Yu
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Weihao Li
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Kai Han
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Wu Jiang
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Leen Liao
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Lingheng Kong
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Yuan Li
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Zhenlin Hou
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Chi Zhou
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Chenzhi Zhang
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Linjie Zhang
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Binyi Xiao
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Weijian Mei
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Yanbo Xu
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Jiayi Qin
- State Key Laboratory of Oncology in South China
- Jian Zheng
- State Key Laboratory of Oncology in South China
- Zhizhong Pan
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- Pei-Rong Ding
- Department of Colorectal Surgery, Sun Yat-sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-35096-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.
