Nature Communications (Feb 2022)
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis
- Yiwu Yan,
- Bo Zhou,
- Chen Qian,
- Alex Vasquez,
- Mohini Kamra,
- Avradip Chatterjee,
- Yeon-Joo Lee,
- Xiaopu Yuan,
- Leigh Ellis,
- Dolores Di Vizio,
- Edwin M. Posadas,
- Natasha Kyprianou,
- Beatrice S. Knudsen,
- Kavita Shah,
- Ramachandran Murali,
- Arkadiusz Gertych,
- Sungyong You,
- Michael R. Freeman,
- Wei Yang
Affiliations
- Yiwu Yan
- Department of Surgery, Cedars-Sinai Medical Center
- Bo Zhou
- Department of Surgery, Cedars-Sinai Medical Center
- Chen Qian
- Department of Surgery, Cedars-Sinai Medical Center
- Alex Vasquez
- Department of Surgery, Cedars-Sinai Medical Center
- Mohini Kamra
- Department of Chemistry and Purdue University Center for Cancer Research, Purdue University
- Avradip Chatterjee
- Department of Biomedical Sciences, Cedars-Sinai Medical Center
- Yeon-Joo Lee
- Department of Surgery, Cedars-Sinai Medical Center
- Xiaopu Yuan
- Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center
- Leigh Ellis
- Department of Biomedical Sciences, Cedars-Sinai Medical Center
- Dolores Di Vizio
- Department of Surgery, Cedars-Sinai Medical Center
- Edwin M. Posadas
- Department of Medicine, Cedars-Sinai Medical Center
- Natasha Kyprianou
- Department of Urology, Icahn School of Medicine at Mount Sinai, New York
- Beatrice S. Knudsen
- Department of Biomedical Sciences, Cedars-Sinai Medical Center
- Kavita Shah
- Department of Chemistry and Purdue University Center for Cancer Research, Purdue University
- Ramachandran Murali
- Department of Biomedical Sciences, Cedars-Sinai Medical Center
- Arkadiusz Gertych
- Department of Surgery, Cedars-Sinai Medical Center
- Sungyong You
- Department of Surgery, Cedars-Sinai Medical Center
- Michael R. Freeman
- Department of Surgery, Cedars-Sinai Medical Center
- Wei Yang
- Department of Surgery, Cedars-Sinai Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-28340-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Distant metastasis is a major reason for mortality in patients with prostate cancer (PC). Here, the authors show that receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and its targeting impairs PC metastasis development.
