Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

Xinyu Xiang; Yu Tao; Jonathan DiRusso; Fei-Man Hsu; Jinchun Zhang; Ziwei Xue; Julien Pontis; Didier Trono; Wanlu Liu; Amander T. Clark

doi:10.1038/s41467-022-28105-1

Nature Communications (Jan 2022)

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

Xinyu Xiang,
Yu Tao,
Jonathan DiRusso,
Fei-Man Hsu,
Jinchun Zhang,
Ziwei Xue,
Julien Pontis,
Didier Trono,
Wanlu Liu,
Amander T. Clark

Affiliations

Xinyu Xiang: Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University
Yu Tao: Department of Molecular Cell and Developmental Biology, University of California, Los Angeles
Jonathan DiRusso: Department of Molecular Cell and Developmental Biology, University of California, Los Angeles
Fei-Man Hsu: Department of Molecular Cell and Developmental Biology, University of California, Los Angeles
Jinchun Zhang: Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University
Ziwei Xue: Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University
Julien Pontis: School of Life Sciences, Ecole Polytechnique Fe ́de ́rale de Lausanne (EPFL)
Didier Trono: School of Life Sciences, Ecole Polytechnique Fe ́de ́rale de Lausanne (EPFL)
Wanlu Liu: Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University
Amander T. Clark: Department of Molecular Cell and Developmental Biology, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-022-28105-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, and LTR5Hs inactivation abrogates human PGC specification

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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