Nature Communications (Sep 2022)
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure
- Shogo Ito,
- Hisayuki Hashimoto,
- Hiroyuki Yamakawa,
- Dai Kusumoto,
- Yohei Akiba,
- Takahiro Nakamura,
- Mizuki Momoi,
- Jin Komuro,
- Toshiomi Katsuki,
- Mai Kimura,
- Yoshikazu Kishino,
- Shin Kashimura,
- Akira Kunitomi,
- Mark Lachmann,
- Masaya Shimojima,
- Gakuto Yozu,
- Chikaaki Motoda,
- Tomohisa Seki,
- Tsunehisa Yamamoto,
- Yoshiki Shinya,
- Takahiro Hiraide,
- Masaharu Kataoka,
- Takashi Kawakami,
- Kunimichi Suzuki,
- Kei Ito,
- Hirotaka Yada,
- Manabu Abe,
- Mizuko Osaka,
- Hiromi Tsuru,
- Masayuki Yoshida,
- Kenji Sakimura,
- Yoshihiro Fukumoto,
- Michisuke Yuzaki,
- Keiichi Fukuda,
- Shinsuke Yuasa
Affiliations
- Shogo Ito
- Department of Cardiology, Keio University School of Medicine
- Hisayuki Hashimoto
- Department of Cardiology, Keio University School of Medicine
- Hiroyuki Yamakawa
- Department of Cardiology, Keio University School of Medicine
- Dai Kusumoto
- Department of Cardiology, Keio University School of Medicine
- Yohei Akiba
- Department of Cardiology, Keio University School of Medicine
- Takahiro Nakamura
- Department of Cardiology, Keio University School of Medicine
- Mizuki Momoi
- Department of Cardiology, Keio University School of Medicine
- Jin Komuro
- Department of Cardiology, Keio University School of Medicine
- Toshiomi Katsuki
- Department of Cardiology, Keio University School of Medicine
- Mai Kimura
- Department of Cardiology, Keio University School of Medicine
- Yoshikazu Kishino
- Department of Cardiology, Keio University School of Medicine
- Shin Kashimura
- Department of Cardiology, Keio University School of Medicine
- Akira Kunitomi
- Department of Cardiology, Keio University School of Medicine
- Mark Lachmann
- Department of Cardiology, Keio University School of Medicine
- Masaya Shimojima
- Department of Cardiology, Keio University School of Medicine
- Gakuto Yozu
- Department of Cardiology, Keio University School of Medicine
- Chikaaki Motoda
- Department of Cardiology, Keio University School of Medicine
- Tomohisa Seki
- Department of Cardiology, Keio University School of Medicine
- Tsunehisa Yamamoto
- Department of Cardiology, Keio University School of Medicine
- Yoshiki Shinya
- Department of Cardiology, Keio University School of Medicine
- Takahiro Hiraide
- Department of Cardiology, Keio University School of Medicine
- Masaharu Kataoka
- Department of Cardiology, Keio University School of Medicine
- Takashi Kawakami
- Department of Cardiology, Keio University School of Medicine
- Kunimichi Suzuki
- Department of Physiology, Keio University School of Medicine
- Kei Ito
- Department of Cardiology, National Defense Medical College
- Hirotaka Yada
- Department of Cardiology, National Defense Medical College
- Manabu Abe
- Department of Animal Model Development, Brain Research Institute, Niigata University
- Mizuko Osaka
- Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Hiromi Tsuru
- Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Masayuki Yoshida
- Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Kenji Sakimura
- Department of Animal Model Development, Brain Research Institute, Niigata University
- Yoshihiro Fukumoto
- Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine
- Michisuke Yuzaki
- Department of Physiology, Keio University School of Medicine
- Keiichi Fukuda
- Department of Cardiology, Keio University School of Medicine
- Shinsuke Yuasa
- Department of Cardiology, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33152-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Right ventricular (RV) failure is clinically crucial, but there is no specific therapy. Here, the authors show that the complement alternative pathway is activated in RV failure and that blockade of the pathway ameliorates RV failure in mice.
