Zhongliu Fangzhi Yanjiu (Aug 2024)

CAR-T Therapy for T-lineage Leukemia: Progress, Dilemmas, and Way Forward

  • Yajing HAN,
  • Liping ZHAO,
  • Kaiting TANG,
  • Qing NIU,
  • Jing PAN,
  • Xiaoming FENG

DOI
https://doi.org/10.3971/j.issn.1000-8578.2024.24.0301
Journal volume & issue
Vol. 51, no. 8
pp. 648 – 654

Abstract

Read online

Tumor immunotherapy occupies a pivotal position in the field of hematological malignancies. Chimeric antigen receptor (CAR) T-cell therapy has established a new therapeutic pattern for hematological immunotherapy and achieved satisfactory clinical results in the treatment of B-lineage hematological malignancies. However, CAR T-cell therapy has some limitations in the treatment of T-cell acute lymphoblastic leukemia because of the presence of CAR T-cell fratricide, tumor cell contamination, T-cell aplasia, and other clinically relevant problems. Therefore, the current major challenge is overcoming the existing bottlenecks to optimize CAR-T therapy and improve its efficacy against T-ALL while improving the prognosis of patients.

Keywords