Prophylactic and Therapeutic Efficacies of Ingavirin®, a Novel Russian Chemotherapeutic, with Respect to Influenza Pathogen A (H5N1)

Abstract

The experimental study of the Ingavirin® efficacy against the influenza virus A (H5N1) on intranasally-infected albino mice vs. Tamiflue® and Arbidol® showed that when used for the prophylaxis, urgent prophylaxis and therapy it was effective in the protec-tiom of the animals from death. The efficient dose for the prophylaxis of the influenza infection was 5 mg/kg (protective efficacy of 46.7%) and for the urgent prophylaxis and therapy it was 15 mg/kg (protective efficacy of 40.0 and 35.0% respectively).

Keywords

• influenza virus a (h5n1)
• ingavirin®
• antiviral efficacy
• prophylaxis
• urgent prophylaxis
• therapy