Clinical neurophysiology of Parkinson’s disease and parkinsonism

Robert Chen; Alfredo Berardelli; Amitabh Bhattacharya; Matteo Bologna; Kai-Hsiang Stanley Chen; Alfonso Fasano; Rick C. Helmich; William D. Hutchison; Nitish Kamble; Andrea A. Kühn; Antonella Macerollo; Wolf-Julian Neumann; Pramod Kumar Pal; Giulia Paparella; Antonio Suppa; Kaviraja Udupa

Clinical Neurophysiology Practice (Jan 2022)

Clinical neurophysiology of Parkinson’s disease and parkinsonism

Robert Chen,
Alfredo Berardelli,
Amitabh Bhattacharya,
Matteo Bologna,
Kai-Hsiang Stanley Chen,
Alfonso Fasano,
Rick C. Helmich,
William D. Hutchison,
Nitish Kamble,
Andrea A. Kühn,
Antonella Macerollo,
Wolf-Julian Neumann,
Pramod Kumar Pal,
Giulia Paparella,
Antonio Suppa,
Kaviraja Udupa

Affiliations

Robert Chen: Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada; Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Corresponding author at: 7MC409, 399 Bathurst St, Toronto, Ontario, M5T 2S8, Canada.
Alfredo Berardelli: Department of Human Neurosciences, Sapienza University of Rome, Italy; IRCCS Neuromed Pozzilli (IS), Italy
Amitabh Bhattacharya: Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India
Matteo Bologna: Department of Human Neurosciences, Sapienza University of Rome, Italy; IRCCS Neuromed Pozzilli (IS), Italy
Kai-Hsiang Stanley Chen: Department of Neurology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan
Alfonso Fasano: Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada; Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
Rick C. Helmich: Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology and Centre of Expertise for Parkinson & Movement Disorders, Nijmegen, the Netherlands
William D. Hutchison: Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Departments of Surgery and Physiology, University of Toronto, Toronto, Ontario, Canada
Nitish Kamble: Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India
Andrea A. Kühn: Department of Neurology, Movement Disorder and Neuromodulation Unit, Charité – Universitätsmedizin Berlin, Germany
Antonella Macerollo: Institute of Systems, Molecular and Integrative Biology, University of Liverpool, United Kingdom; The Walton Centre NHS Foundation Trust for Neurology and Neurosurgery, Liverpool, United Kingdom
Wolf-Julian Neumann: Department of Neurology, Movement Disorder and Neuromodulation Unit, Charité – Universitätsmedizin Berlin, Germany
Pramod Kumar Pal: Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India
Giulia Paparella: IRCCS Neuromed Pozzilli (IS), Italy
Antonio Suppa: Department of Human Neurosciences, Sapienza University of Rome, Italy; IRCCS Neuromed Pozzilli (IS), Italy
Kaviraja Udupa: Department of Neurophysiology National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India

Journal volume & issue: Vol. 7
pp. 201 – 227

Abstract

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This review is part of the series on the clinical neurophysiology of movement disorders. It focuses on Parkinson’s disease and parkinsonism. The topics covered include the pathophysiology of tremor, rigidity and bradykinesia, balance and gait disturbance and myoclonus in Parkinson’s disease. The use of electroencephalography, electromyography, long latency reflexes, cutaneous silent period, studies of cortical excitability with single and paired transcranial magnetic stimulation, studies of plasticity, intraoperative microelectrode recordings and recording of local field potentials from deep brain stimulation, and electrocorticography are also reviewed. In addition to advancing knowledge of pathophysiology, neurophysiological studies can be useful in refining the diagnosis, localization of surgical targets, and help to develop novel therapies for Parkinson’s disease.

Published in Clinical Neurophysiology Practice

ISSN: 2467-981X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/clinical-neurophysiology-practice

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