Nature Communications (Jan 2020)
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis
- Kerrie L. Marie,
- Antonella Sassano,
- Howard H. Yang,
- Aleksandra M. Michalowski,
- Helen T. Michael,
- Theresa Guo,
- Yien Che Tsai,
- Allan M. Weissman,
- Maxwell P. Lee,
- Lisa M. Jenkins,
- M. Raza Zaidi,
- Eva Pérez-Guijarro,
- Chi-Ping Day,
- Kris Ylaya,
- Stephen M. Hewitt,
- Nimit L. Patel,
- Heinz Arnheiter,
- Sean Davis,
- Paul S. Meltzer,
- Glenn Merlino,
- Pravin J. Mishra
Affiliations
- Kerrie L. Marie
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Antonella Sassano
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Howard H. Yang
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Aleksandra M. Michalowski
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Helen T. Michael
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Theresa Guo
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Yien Che Tsai
- Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute
- Allan M. Weissman
- Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute
- Maxwell P. Lee
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Lisa M. Jenkins
- Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- M. Raza Zaidi
- Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University
- Eva Pérez-Guijarro
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Chi-Ping Day
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Kris Ylaya
- Experimental Pathology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Stephen M. Hewitt
- Experimental Pathology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Nimit L. Patel
- Small Animal Imaging Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc.
- Heinz Arnheiter
- Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institute of Health
- Sean Davis
- Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Paul S. Meltzer
- Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Glenn Merlino
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Pravin J. Mishra
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-019-14085-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Metastatic cells can mimic many of the phenotypic behaviors of embryonic cells. Here, the authors generate a melanoblast-specific transcriptome using a genetically engineered mouse model and identify KDELR3 as a pro-metastasis gene in melanoma.
