Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period

Abstract

Objective: CRP was the most commonly used marker of inflammation in renal transplant recipients in chronic renal disease, and renal functions were monitored with creatinine levels. In this study, we recorded the early course of B2 microglobulin and pentraxin levels as inflammatory markers in renal transplant patients and aimed to determine its usefulness as markers of inflammation. Materials and Methods: This is a prospective observation study of 23 adult patients who underwent renal transplantation from living donors between January and June 2017. Demographic characteristics, blood samples, biochemical parameters and inflammation markers were studied on the first day, 3rd day, 7th day and 30th day after transplantation. Results: 18 (78%) of the 23 patients included in our study were in the pre-transplant dialysis program and 5 (22%) received preemptive dialysis. There were significant decreases in B2 microglobulin levels on the first postoperative day on the 3rd day and 7th day (p 0.05). Creatinine levels decreased significantly on the third day compared to the first day. There was a significant positive correlation between B2 microglobulin and creatinine at postoperative day 0, day 3, day 7 and month 1 (p <0.05). Pentraxine and CRP levels increased significantly on the third day compared to the first day, then decreased significantly on the 7th day and the first month. (P <0.05) However, there was no significant correlation between pentraxin changes and CRP changes. Conclusion: Early detection of inflammation in renal transplant recipients is important for the risk of graft rejection. B2 microglobulin and pentraxin levels may be used as new markers for graft rejection and renal function evaluation, but randomized controlled trials with larger patient numbers are needed.

Keywords

• b2-microglobulin
• inflammation
• pentraxin
• transplantation