MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells

Charlène Estrada; Liliana Mirabal-Ortega; Laurence Méry; Florent Dingli; Laetitia Besse; Cedric Messaoudi; Damarys Loew; Celio Pouponnot; Corine Bertolotto; Alain Eychène; Sabine Druillennec

doi:10.1038/s42003-022-03049-w

Communications Biology (Jan 2022)

MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells

Charlène Estrada,
Liliana Mirabal-Ortega,
Laurence Méry,
Florent Dingli,
Laetitia Besse,
Cedric Messaoudi,
Damarys Loew,
Celio Pouponnot,
Corine Bertolotto,
Alain Eychène,
Sabine Druillennec

Affiliations

Charlène Estrada: Institut Curie, Centre de Recherche
Liliana Mirabal-Ortega: Institut Curie, Centre de Recherche
Laurence Méry: Institut Curie, Centre de Recherche
Florent Dingli: Institut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique
Laetitia Besse: Institut Curie, PSL Research University
Cedric Messaoudi: Institut Curie, PSL Research University
Damarys Loew: Institut Curie, PSL Research University, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique
Celio Pouponnot: Institut Curie, Centre de Recherche
Corine Bertolotto: Université Côte d’Azur, INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M)
Alain Eychène: Institut Curie, Centre de Recherche
Sabine Druillennec: Institut Curie, Centre de Recherche

DOI: https://doi.org/10.1038/s42003-022-03049-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The MITF transcription factor directly binds to the kinase domain of RAF kinases, including ARAF, BRAF and CRAF in melanoma cells. RAF/MITF complex promotes cytoplasmic accumulation of MITF and thus negatively regulates its transcriptional activity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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