Nature Communications (Jan 2022)
Characterization of the COPD alveolar niche using single-cell RNA sequencing
- Maor Sauler,
- John E. McDonough,
- Taylor S. Adams,
- Neeharika Kothapalli,
- Thomas Barnthaler,
- Rhiannon B. Werder,
- Jonas C. Schupp,
- Jessica Nouws,
- Matthew J. Robertson,
- Cristian Coarfa,
- Tao Yang,
- Maurizio Chioccioli,
- Norihito Omote,
- Carlos Cosme,
- Sergio Poli,
- Ehab A. Ayaub,
- Sarah G. Chu,
- Klaus H. Jensen,
- Jose L. Gomez,
- Clemente J. Britto,
- Micha Sam B. Raredon,
- Laura E. Niklason,
- Andrew A. Wilson,
- Pascal N. Timshel,
- Naftali Kaminski,
- Ivan O. Rosas
Affiliations
- Maor Sauler
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- John E. McDonough
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Taylor S. Adams
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Neeharika Kothapalli
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Thomas Barnthaler
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Rhiannon B. Werder
- Center for Regenerative Medicine of Boston University and Boston Medical Center
- Jonas C. Schupp
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Jessica Nouws
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Matthew J. Robertson
- Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine
- Cristian Coarfa
- Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine
- Tao Yang
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Maurizio Chioccioli
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Norihito Omote
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Carlos Cosme
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Sergio Poli
- Department of Internal Medicine, Mount Sinai Medical Center
- Ehab A. Ayaub
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Sarah G. Chu
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Klaus H. Jensen
- Intomics A/S
- Jose L. Gomez
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Clemente J. Britto
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Micha Sam B. Raredon
- Department of Biomedical Engineering, Yale University
- Laura E. Niklason
- Department of Biomedical Engineering, Yale University
- Andrew A. Wilson
- Center for Regenerative Medicine of Boston University and Boston Medical Center
- Pascal N. Timshel
- Intomics A/S
- Naftali Kaminski
- Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Ivan O. Rosas
- Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-28062-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Chronic obstructive pulmonary disease is a leading cause of death worldwide, while our understanding of cell-specific mechanisms underlying its pathobiology remains incomplete. Here the authors perform scRNA-seq of human lung tissue to identify transcriptional changes in alveolar niche cells associated with the disease.
