Diabetes, Metabolic Syndrome and Obesity (Dec 2023)

Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment

  • Li J,
  • Zhu N,
  • Wang Y,
  • Bao Y,
  • Xu F,
  • Liu F,
  • Zhou X

Journal volume & issue
Vol. Volume 16
pp. 4269 – 4282

Abstract

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Jing Li,1,* Na Zhu,2,* Yaqiong Wang,2 Yanlei Bao,3 Feng Xu,2 Fengjuan Liu,2 Xuefeng Zhou2 1Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, People’s Republic of China; 2Clinical Trial Research Center, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Central Hospital, Qingdao, People’s Republic of China; 3Department of Pharmacy, Liaoyuan People’s Hospital, Liaoyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuefeng Zhou, Clinical Trial Research Center, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Central Hospital, No. 127, Siliunan Road, Shibei District, Qingdao, Shandong, 266042, People’s Republic of China, Tel +86 18561856181, Email [email protected]: Diabetes is a major global public health problem with high incidence and case fatality rates. Traditional Chinese medicine (TCM) is used to help manage Type 2 Diabetes Mellitus (T2DM) and has steadily gained international acceptance. Despite being generally accepted in daily practice, the TCM methods and hypotheses for understanding diseases lack applicability in the current scientific characterization systems. To date, there is no systematic evaluation system for TCM in preventing and treating T2DM. Metabonomics is a powerful tool to predict the level of metabolites in vivo, reveal the potential mechanism, and diagnose the physiological state of patients in time to guide the follow-up intervention of T2DM. Notably, metabolomics is also effective in promoting TCM modernization and advancement in personalized medicine. This review provides updated knowledge on applying metabolomics to TCM syndrome differentiation, diagnosis, biomarker discovery, and treatment of T2DM by TCM. Its application in diabetic complications is discussed. The combination of multi-omics and microbiome to fully elucidate the use of TCM to treat T2DM is further envisioned.Keywords: metabolomics, traditional Chinese medicine, type 2 diabetes mellitus, diabetic complications, diagnosis

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