JHEP Reports (Jun 2021)
Assessing the impact of COVID-19 on liver cancer management (CERO-19)
- Sergio Muñoz-Martínez,
- Victor Sapena,
- Alejandro Forner,
- Jean-Charles Nault,
- Gonzalo Sapisochin,
- Lorenza Rimassa,
- Bruno Sangro,
- Jordi Bruix,
- Marco Sanduzzi-Zamparelli,
- Wacław Hołówko,
- Mohamed El Kassas,
- Tudor Mocan,
- Mohamed Bouattour,
- Philippe Merle,
- Frederik J.H. Hoogwater,
- Saleh A. Alqahtani,
- Helen L. Reeves,
- David J. Pinato,
- Emmanouil Giorgakis,
- Tim Meyer,
- Gerda Elisabeth Villadsen,
- Henning Wege,
- Massimiliano Salati,
- Beatriz Mínguez,
- Giovan Giuseppe Di Costanzo,
- Christoph Roderburg,
- Frank Tacke,
- María Varela,
- Peter R. Galle,
- Mario Reis Alvares-da-Silva,
- Jörg Trojan,
- John Bridgewater,
- Giuseppe Cabibbo,
- Christian Toso,
- Anja Lachenmayer,
- Andrea Casadei-Gardini,
- Hidenori Toyoda,
- Tom Lüdde,
- Rosanna Villani,
- Ana María Matilla Peña,
- Cassia Regina Guedes Leal,
- Monica Ronzoni,
- Manuel Delgado,
- Christie Perelló,
- Sonia Pascual,
- José Luis Lledó,
- Josepmaria Argemi,
- Bristi Basu,
- Leonardo da Fonseca,
- Juan Acevedo,
- Alexander R. Siebenhüner,
- Chiara Braconi,
- Brandon M. Meyers,
- Alessandro Granito,
- Margarita Sala,
- Carlos Rodríguez-Lope,
- Lorraine Blaise,
- Manuel Romero-Gómez,
- Federico Piñero,
- Dhanny Gomez,
- Vivianne Mello,
- Rogerio Camargo Pinheiro Alves,
- Alex França,
- Fernanda Branco,
- Giovanni Brandi,
- Gustavo Pereira,
- Susanna Coll,
- Maria Guarino,
- Carlos Benítez,
- Maria Margarita Anders,
- Juan C. Bandi,
- Mercedes Vergara,
- Mariona Calvo,
- Markus Peck-Radosavljevic,
- Ignacio García-Juárez,
- Vincenzo Cardinale,
- Mar Lozano,
- Martina Gambato,
- Stefano Okolicsanyi,
- Dalia Morales-Arraez,
- Alessandra Elvevi,
- Alberto E. Muñoz,
- Alberto Lué,
- Massimo Iavarone,
- Maria Reig
Affiliations
- Sergio Muñoz-Martínez
- BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
- Victor Sapena
- BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
- Alejandro Forner
- BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
- Jean-Charles Nault
- Service d’hépatologie, Hôpital Avicenne, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bobigny, France; Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris Nord, Paris, France; Centre de Recherche des Cordeliers, Inserm, Sorbonne Université, Université Paris, INSERM UMR 1138 Functional Genomics of Solid Tumors Laboratory, Paris, France
- Gonzalo Sapisochin
- Abdominal Transplant & HPB Surgical Oncology, University Health Network, Toronto General Hospital, University of Toronto, Toronto, Canada
- Lorenza Rimassa
- Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center – IRCCS, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy
- Bruno Sangro
- Unidad de Hepatología, Clínica Universidad de Navarra, IDISNA, CIBERehd, Pamplona, Spain
- Jordi Bruix
- BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
- Marco Sanduzzi-Zamparelli
- BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain
- Wacław Hołówko
- Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland
- Mohamed El Kassas
- Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt
- Tudor Mocan
- 3rd Medical Department, ‘Octavian Fodor’ Institute for Gastroenterology and Hepatology, Cluj-Napoca, Romania
- Mohamed Bouattour
- AP-HP, Hôpital Beaujon, Department of Digestive Oncology, Clichy, France
- Philippe Merle
- Department of Hepatology, Groupement Hospitalier Lyon Nord, Lyon, France
- Frederik J.H. Hoogwater
- Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands
- Saleh A. Alqahtani
- Department of Liver Transplant, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
- Helen L. Reeves
- Liver Unit, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
- David J. Pinato
- Department of Surgery and Cancer, Imperial College London, London, UK
- Emmanouil Giorgakis
- Division of Transplantation, Department of Surgery, UAMS Medical Center, Winthrop P. Rockefeller Cancer Institute, Little Rock, AK, USA
- Tim Meyer
- Department of Oncology, Royal Free Hospital, London, UK
- Gerda Elisabeth Villadsen
- Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
- Henning Wege
- Department of Internal Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Massimiliano Salati
- Department of Clinical and Experimental Medicine, University Hospital of Modena and Reggio Emilia, Modena, Emilia-Romagna, Italy
- Beatriz Mínguez
- Liver Unit, Hospital Universitari Vall d’Hebron, Liver Diseases Research Group, Vall d'Hebron Institut of Research (VHIR), Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona, Barcelona, Spain
- Giovan Giuseppe Di Costanzo
- Liver Unit, A Cardarelli Hospital, Naples, Italy
- Christoph Roderburg
- Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany
- Frank Tacke
- Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany
- María Varela
- Department of Gastroenterology and Hepatology. Hospital Universitario Central de Asturias, IUOPA, ISPA, Universidad de Oviedo, Oviedo, Spain
- Peter R. Galle
- I. Department of Internal Medicine, University Medical Center Mainz, Mainz, Germany
- Mario Reis Alvares-da-Silva
- GI/Liver Unit, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
- Jörg Trojan
- Medical Clinic 1, Goethe University Hospital, Frankfurt, Germany
- John Bridgewater
- Department of Oncology, University College of London, London, UK
- Giuseppe Cabibbo
- Section of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy
- Christian Toso
- Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
- Anja Lachenmayer
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, Bern, Switzerland
- Andrea Casadei-Gardini
- Department of Medical Oncology, University of Modena and Reggio Emilia, Modena, Italy
- Hidenori Toyoda
- Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
- Tom Lüdde
- Clinic for Gastroenterology, Hepatology and Infectious Disease, University Hospital Düsseldorf, Düsseldorf, Germany
- Rosanna Villani
- Liver Unit, Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy
- Ana María Matilla Peña
- Gastroenterology and Hepatology, H.G.U. Gregorio Marañon, CIBERehd, Madrid, Spain
- Cassia Regina Guedes Leal
- Gastroenterology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil
- Monica Ronzoni
- Medical Oncology Unit, IRCCS Ospedale San Raffaele, Milan, Italy
- Manuel Delgado
- Department of Digestive Disease, University Hospital La Coruña, La Coruña, Spain
- Christie Perelló
- Department of Gastroenterology and Hepatology, University Hospital Puerta de Hierro, Majadahonda, Spain
- Sonia Pascual
- Liver Unit, HGU Alicante, CIBERehd, Alicante, Spain
- José Luis Lledó
- Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Madrid, Spain
- Josepmaria Argemi
- Internal Medicine - Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain
- Bristi Basu
- Department of Oncology, University of Cambridge, Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
- Leonardo da Fonseca
- Department of Clinical Oncology, Sao Paulo Clinicas Liver Cancer group, Insitituto do Cancer do Estado de São Paulo, University of São Paulo, San Paulo, Brazil
- Juan Acevedo
- South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK
- Alexander R. Siebenhüner
- Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
- Chiara Braconi
- Department of Medical Oncology, Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK
- Brandon M. Meyers
- Department of Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada
- Alessandro Granito
- Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Margarita Sala
- Department of Gastroenterology, Hepatology Unit, Hospital Doctor Josep Trueta, CIBERehd, Girona, Spain
- Carlos Rodríguez-Lope
- Servicio de Aparato Digestivo, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
- Lorraine Blaise
- Service d’hépatologie, Hôpital Avicenne, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bobigny, France; Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris Nord, Paris, France; Centre de Recherche des Cordeliers, Inserm, Sorbonne Université, Université Paris, INSERM UMR 1138 Functional Genomics of Solid Tumors Laboratory, Paris, France
- Manuel Romero-Gómez
- SeLiver group, UGC de Enfermedades Digestivas, Instituto de Biomedicina de Sevilla, Hospital Virgen del Rocío, CIBERehd, Seville, Spain
- Federico Piñero
- Liver Unit, Hospital Universitario Austral, Pilar, Argentina
- Dhanny Gomez
- HPB Surgery and Hepatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
- Vivianne Mello
- Department of Oncology, AMO Clinic, Salvador, Brazil
- Rogerio Camargo Pinheiro Alves
- Department of Gastroenterology, Hospital do Servidor Publico Estadual de São Paulo, San Paulo, Brazil
- Alex França
- Department of Medicine, Federal University of Sergipe, Aracaju, Brazil
- Fernanda Branco
- Department of Hepatology, CliniOnco, Porto Alegre, Brazil
- Giovanni Brandi
- Division of Oncology – Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy
- Gustavo Pereira
- Gastroenterology and Hepatology Unit, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil
- Susanna Coll
- Hepatology Section, Gastroenterology Department, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
- Maria Guarino
- Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
- Carlos Benítez
- Department of Gastroenterology, Pontificia Universidad Católica de Chile, Santiago, Chile
- Maria Margarita Anders
- Sección Hepatología, Hospital Aleman, Buenos Aires, Argentina
- Juan C. Bandi
- Department of Hepatology, Hospital Italiano, Buenos Aires, Argentina
- Mercedes Vergara
- Unitat d’Hepatologia, Servei d’Aparell Digestiu, Parc Taulí Sabadell Hospital Universitari, Institut d’Investigació i Innovació I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; CIBERehd, Instituto Carlos III, Madrid, Spain
- Mariona Calvo
- Oncología Médica, Institut Català d’Oncologia, L’Hospitalet del Llobregat, Barcelona, Spain
- Markus Peck-Radosavljevic
- Innere Medizin & Gastroenterologie, Klinikum Klagenfurt am Wörthersee, Klagenfurt am Wörthersee, Austria
- Ignacio García-Juárez
- Gastroenterology Department, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico
- Vincenzo Cardinale
- Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Italy
- Mar Lozano
- Aparato Digestivo, Hospital Universitario Infanta Leonor, Madrid, Spain
- Martina Gambato
- Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy; Multivisceral Transplant Unit, Gastroenterology, Padua University Hospital, Padua, Italy
- Stefano Okolicsanyi
- Department of Surgical Disciplines, Gastroenterology and Digestive Endoscopy, Umberto Parini Hospital, Aosta, Italy
- Dalia Morales-Arraez
- Department of Gastroenterology and Hepatology, Hospital Universitario de Canarias, La Laguna, Spain
- Alessandra Elvevi
- Division of Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital University of Milano–Bicocca School of Medicine, Monza, Italy
- Alberto E. Muñoz
- Sección Hepatología, Hospital Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina
- Alberto Lué
- Gastroenterology, Hepatology and Nutrition Unit, San Jorge General Hospital, Huesca, Spain
- Massimo Iavarone
- Foundation IRCCS Ca’ Granada Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, CRC ‘A.M. and A. Migliavacca’ Center for Liver Disease, Milan, Italy; Corresponding authors. Addresses: Foundation IRCCS Ca’ Granada Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, CRC ‘A.M. and A. Migliavacca’ Center for Liver Disease, Milan, Italy
- Maria Reig
- BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain; BCLC group, Liver Unit, IMDiM, CIBERehd, IDIBAPS, Hospital Clínic, c/ Villarroel, 170, Escala 11, 4a planta, 08036 Barcelona, Spain. Tel.: +34 93 227 9803; fax: +34 93 227 5792.
- Journal volume & issue
-
Vol. 3,
no. 3
p. 100260
Abstract
Background & Aims: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic. Methods: An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave. Results: Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37). Conclusions: The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making. Lay summary: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes.
