The impact of genetic factors on thyroid hormones metabolism in patients with diabetic kidney disease

Abstract

One out of eleven adults in the world has diabetes mellitus. 25% of them develop diabetic kidney disease. Thyroid hormones are involved in the regulation of almost all physiological processes in the body, including renal function. The aim of the research was to study the dependance of biochemical markers of renal function in patients with diabetic kidney disease on C/Т polymоrphism in the DIO1 gene. To assess the dependence of biochemical markers of renal function on the C/T polymorphism in the DIO1 gene, the following groups has been formed: 19 patients with CC genotype, 69 individuals – with CT and 14 ones- with TT genotypes. Content of urea and cleatinine in plasma, eGFR, as well as microalbumine and creatinine content in urine were sagnificantly higher in patients with TT genotype than in group of patients with CC genotype and control group (P < 0.05). Presence of the T allele in genotype is associated with violation of thyroid hormones metabolism with the development of nonthyroidal illness syndrome. Carriers of T allele with diabetic kidney disease had significantly worse biochemical indices of renal function, that indicates the dependence of these markers on DIO1 polymorphism.

Keywords

• biochemical indices of renal function
• c/t polymorphism in the dio 1 gene
• diabetic kidney disease
• nonthyriodal illness syndrome
• thyroid status assessment