Traditional Chinese medicine attenuates hospitalization and mortality risks in diabetic patients with carcinoma in situ in Taiwan

Li-Jen Tsai; Chi-Hsiang Chung; Chien-Jung Lin; Sheng-Chiang Su; Feng-Chih Kuo; Jhih-Syuan Liu; Kuan-Chan Chen; Li-Ju Ho; Chih-Chun Kuo; Chun-Yung Chang; Ming-Hsun Lin; Nain-Feng Chu; Chien-Hsing Lee; Chang-Hsun Hsieh; Yi-Jen Hung; Po-Shiuan Hsieh; Fu-Huang Lin; Chieh-Hua Lu; Wu-Chien Chien

Integrative Medicine Research (Jun 2022)

Traditional Chinese medicine attenuates hospitalization and mortality risks in diabetic patients with carcinoma in situ in Taiwan

Li-Jen Tsai,
Chi-Hsiang Chung,
Chien-Jung Lin,
Sheng-Chiang Su,
Feng-Chih Kuo,
Jhih-Syuan Liu,
Kuan-Chan Chen,
Li-Ju Ho,
Chih-Chun Kuo,
Chun-Yung Chang,
Ming-Hsun Lin,
Nain-Feng Chu,
Chien-Hsing Lee,
Chang-Hsun Hsieh,
Yi-Jen Hung,
Po-Shiuan Hsieh,
Fu-Huang Lin,
Chieh-Hua Lu,
Wu-Chien Chien

Affiliations

Li-Jen Tsai: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan (Province of China)
Chi-Hsiang Chung: School of Public Health, National Defense Medical Center, Taipei, Taiwan (Province of China); Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan (Province of China)
Chien-Jung Lin: Department of Chinese Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Province of China)
Sheng-Chiang Su: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Feng-Chih Kuo: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Jhih-Syuan Liu: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Kuan-Chan Chen: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Li-Ju Ho: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Chih-Chun Kuo: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Chun-Yung Chang: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Ming-Hsun Lin: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Nain-Feng Chu: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Chien-Hsing Lee: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China); Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Province of China)
Chang-Hsun Hsieh: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Yi-Jen Hung: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China); Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China)
Po-Shiuan Hsieh: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Province of China); Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan (Province of China)
Fu-Huang Lin: School of Public Health, National Defense Medical Center, Taipei, Taiwan (Province of China)
Chieh-Hua Lu: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan (Province of China); Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Province of China); Corresponding author at: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, 7115R, No. 325, Section 2, Cheng-Kung Road, Neihu District, Taipei City 11490, Taiwan, Republic of China.
Wu-Chien Chien: School of Public Health, National Defense Medical Center, Taipei, Taiwan (Province of China); Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Province of China)

Journal volume & issue: Vol. 11, no. 2
p. 100831

Abstract

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Background: Diabetic patients are at high risk of developing cancer. Traditional Chinese medicine (TCM) has become increasingly popular as an adjuvant treatment for patients with chronic diseases, and some studies have identified its beneficial effect in diabetic patients with cancer. The purpoes of this study was to outline the potential of TCM to attenuate hospitalization and mortality rates in diabetic patients with carcinoma in situ (CIS). Methods: A total of 6,987 diabetic subjects with CIS under TCM therapy were selected from the National Health Insurance Research Database of Taiwan, along with 38,800 of 1:1 sex-, age-, and index year-matched controls without TCM therapy. Cox proportional hazard analysis was conducted to compare hospitalization and mortality rates during an average of 15 years of follow-up. Results: A total of 3,999/1,393 enrolled-subjects (28.62%/9.97%) had hospitalization/mortality, including 1,777/661 in the TCM group (25.43%/9.46%) and 2,222/732 in the control group (31.80%/10.48%). Cox proportional hazard regression analysis showed a lower rate of hospitalization and mortality for subjects in the TCM group (adjusted HR=0.536; 95% CI=0.367–0.780, P<0.001; adjusted HR=0.783; 95% CI=0.574–0.974, P = 0.022). Kaplan-Meier analysis showed that the cumulative risk of hospitalization and mortality in the case and control groups was significantly different (log rank, P<0.001 and P = 0.011, respectively). Conclusions: Diabetic patients with CIS under TCM therapy were associated with lower hospitalization and mortality rates compared to those without TCM therapy. Thus, TCM application may reduce the burden of national medical resources.

Published in Integrative Medicine Research

ISSN: 2213-4220 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Other systems of medicine: Miscellaneous systems and treatments
Website: http://www.journals.elsevier.com/integrative-medicine-research/

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