Nature Communications (Apr 2023)
Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma
- Zhihong Chen,
- Nishant Soni,
- Gonzalo Pinero,
- Bruno Giotti,
- Devon J. Eddins,
- Katherine E. Lindblad,
- James L. Ross,
- Montserrat Puigdelloses Vallcorba,
- Tanvi Joshi,
- Angelo Angione,
- Wes Thomason,
- Aislinn Keane,
- Nadejda M. Tsankova,
- David H. Gutmann,
- Sergio A. Lira,
- Amaia Lujambio,
- Eliver E. B. Ghosn,
- Alexander M. Tsankov,
- Dolores Hambardzumyan
Affiliations
- Zhihong Chen
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Nishant Soni
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Gonzalo Pinero
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Bruno Giotti
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Devon J. Eddins
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Winship Cancer Institute, Emory University School of Medicine
- Katherine E. Lindblad
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- James L. Ross
- Emory University Department of Microbiology and Immunology, Emory Vaccine Center
- Montserrat Puigdelloses Vallcorba
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Tanvi Joshi
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Angelo Angione
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Wes Thomason
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Aislinn Keane
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Nadejda M. Tsankova
- Department of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai
- David H. Gutmann
- Department of Neurology, Washington University School of Medicine
- Sergio A. Lira
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Amaia Lujambio
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Eliver E. B. Ghosn
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Winship Cancer Institute, Emory University School of Medicine
- Alexander M. Tsankov
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Dolores Hambardzumyan
- Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-023-37361-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 24
Abstract
Myeloid cells are the predominant cell type in the tumor microenvironment of human and murine glioblastoma (GBM). By generating a mouse model deficient for all monocyte chemoattractant proteins, here the authors show that blocking monocyte recruitment promotes a compensatory neutrophil influx and that concomitant neutrophil inhibition is required to improve survival in GBM preclinical models.
