TOXIGENCE OF ANTHRAX VACCINE STRAINS

Abstract

The article presents the results of the studying of anthrax strains and Bacillus anthracis-like strains on the formation of toxins. We found that anthrax vaccine strains actively produce exotoxins to the culture fluid. The amount of specific protein is different under the same incubation conditions and depends on the individual characteristics of the microorganism population, because of this, different titers of the toxin are registered. Strain B. anthracis K-79 Z (vaccine) with the same number of planting microbial cells and growing on the same culture medium and at the same temperature produces by two orders of magnitude more exotoxin than strains B. anthracis Tsenkovsky II IBM 92Z (virulent), B. anthracis Stern 34F2, (vaccine), B. anthracis 55 (vaccine), B. anthracis SB (vaccine), B. anthracis Tsenkovsky I (vaccine, аpathogenic). The amount of exotoxin may change if the pH of the medium changes. The activity of exotoxin production, when the pH changes, depends on the characteristics of the anthrax strain.

Keywords

• anthrax
• exotoxin
• exotoxin production