Nature Communications (Jan 2018)

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

  • Rahul Nahar,
  • Weiwei Zhai,
  • Tong Zhang,
  • Angela Takano,
  • Alexis J. Khng,
  • Yin Yeng Lee,
  • Xingliang Liu,
  • Chong Hee Lim,
  • Tina P. T. Koh,
  • Zaw Win Aung,
  • Tony Kiat Hon Lim,
  • Lavanya Veeravalli,
  • Ju Yuan,
  • Audrey S. M. Teo,
  • Cheryl X. Chan,
  • Huay Mei Poh,
  • Ivan M. L. Chua,
  • Audrey Ann Liew,
  • Dawn Ping Xi Lau,
  • Xue Lin Kwang,
  • Chee Keong Toh,
  • Wan-Teck Lim,
  • Bing Lim,
  • Wai Leong Tam,
  • Eng-Huat Tan,
  • Axel M. Hillmer,
  • Daniel S. W. Tan

DOI
https://doi.org/10.1038/s41467-017-02584-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance.