Nature Communications (Mar 2020)

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

  • Michelle Schorer,
  • Katharina Lambert,
  • Nikolas Rakebrandt,
  • Felix Rost,
  • Kung-Chi Kao,
  • Alexander Yermanos,
  • Roman Spörri,
  • Josua Oderbolz,
  • Miro E. Raeber,
  • Christian W. Keller,
  • Jan D. Lünemann,
  • Gerhard Rogler,
  • Onur Boyman,
  • Annette Oxenius,
  • Nicole Joller

DOI
https://doi.org/10.1038/s41467-020-15309-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Viral infection transiently depletes T regulatory cells (Treg). Here the authors identify a compensatory induced Treg population, which is required to rapidly replenish the Treg niche and suppress microbiota-driven, virus-induced colitis.