The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

Vera Vorstandlechner; Maria Laggner; Dragan Copic; Katharina Klas; Martin Direder; Yiyan Chen; Bahar Golabi; Werner Haslik; Christine Radtke; Erwin Tschachler; Konrad Hötzenecker; Hendrik Jan Ankersmit; Michael Mildner

doi:10.1038/s41467-021-26495-2

Nature Communications (Oct 2021)

The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

Vera Vorstandlechner,
Maria Laggner,
Dragan Copic,
Katharina Klas,
Martin Direder,
Yiyan Chen,
Bahar Golabi,
Werner Haslik,
Christine Radtke,
Erwin Tschachler,
Konrad Hötzenecker,
Hendrik Jan Ankersmit,
Michael Mildner

Affiliations

Vera Vorstandlechner: Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Thoracic Surgery, Medical University of Vienna
Maria Laggner: Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Thoracic Surgery, Medical University of Vienna
Dragan Copic: Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Thoracic Surgery, Medical University of Vienna
Katharina Klas: Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Thoracic Surgery, Medical University of Vienna
Martin Direder: Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Thoracic Surgery, Medical University of Vienna
Yiyan Chen: Department of Dermatology, Medical University of Vienna
Bahar Golabi: Department of Dermatology, Medical University of Vienna
Werner Haslik: Department of Plastic and Reconstructive Surgery, Medical University of Vienna
Christine Radtke: Department of Plastic and Reconstructive Surgery, Medical University of Vienna
Erwin Tschachler: Department of Dermatology, Medical University of Vienna
Konrad Hötzenecker: Department of Thoracic Surgery, Medical University of Vienna
Hendrik Jan Ankersmit: Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Department of Thoracic Surgery, Medical University of Vienna
Michael Mildner: Department of Dermatology, Medical University of Vienna

DOI: https://doi.org/10.1038/s41467-021-26495-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Mechanisms triggering hypertrophic scar formation remain poorly understood. Here the authors perform scRNA-seq on mature human hypertrophic scars and developing scars in mice to identify the serine proteases dipeptidyl-peptidase 4 and urokinase as key molecules in this process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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