Synthesis of ribavirin 2’-Me-C-nucleoside analogues

Abstract

An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2’-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.

Keywords

• alkynylation
• antiviral
• cancer
• C-nucleosides
• ribavirin