Therapeutic Advances in Neurological Disorders (Apr 2024)

Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China

  • Jun Guo,
  • Jiayong Wu,
  • Lihua Wang,
  • Hongbo Liu,
  • Xiaomu Wu,
  • Huan Yang,
  • Wenyu Li,
  • Honghao Wang,
  • Bitao Bu,
  • Chunsheng Yang,
  • Hongyu Zhou,
  • Shougang Guo,
  • Yinan Zhao,
  • Zhanhang Wang,
  • Chunyang Li,
  • De-Cai Tian,
  • Sheng Chen,
  • Huiru Xue,
  • Yanlin Zhang,
  • Yongfeng Xu,
  • Hui Liang,
  • Zhe Wu,
  • Yu Zhang,
  • Qiang Dong,
  • Jiawei Wang,
  • Chao Quan

DOI
https://doi.org/10.1177/17562864241239117
Journal volume & issue
Vol. 17

Abstract

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Multiple sclerosis (MS) was defined as a rare disease in China due to its low prevalence. For a long time, interferon β was the only approved disease-modifying therapy (DMT). Since the first oral DMT was approved in 2018, DMT approval accelerated, and seven DMTs were approved within 5 years. With an increasing number of DMTs being prescribed in clinical practice, it is necessary to discuss the standardized MS treatment algorithms depending on the disease activity and DMT availability. In this review paper, more than 20 Chinese experts in MS have reviewed the therapeutic progress of MS in China and worldwide and discussed algorithms for treating relapsing MS (RMS) based on the available DMTs in China, providing insights for establishing the standardized RMS treatment algorithms in this country.