Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids
Otemberg Souza Chaves,
Yanna Carolina Ferreira Teles,
Matheus Morais de Oliveira Monteiro,
Leônidas das Graças Mendes Junior,
Maria de Fátima Agra,
Valdir de Andrade Braga,
Tânia Maria Sarmento Silva,
Maria de Fátima Vanderlei de Souza
Affiliations
Otemberg Souza Chaves
Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
Yanna Carolina Ferreira Teles
Post Graduation in Development and Technological Innovation in Medicines, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil
Matheus Morais de Oliveira Monteiro
Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
Leônidas das Graças Mendes Junior
Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
Maria de Fátima Agra
Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
Valdir de Andrade Braga
Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
Tânia Maria Sarmento Silva
Department of Molecular Sciences, Federal Rural University of Pernambuco, Campus Dois Irmãos, 52171-900 Recife, PE, Brazil
Maria de Fátima Vanderlei de Souza
Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6′′-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries.
